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IMD-1

Chemical Structure : IMD-1

CAS No.: 251907-19-4

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IMD-1

Catalog No.: PC-27815Not For Human Use, Lab Use Only.

IMD-1 is a potent dual inhibitor of acetylcholine and butyrylcholine esterases (AChE and BChE) with IC50 of 34.6 nM and 49.04 nM, protects SH-SY5Y cells against H2O2-induced oxidative injury by modulating oxidative stress, mitochondrial dysfunction, inflammatory mediator release, and apoptosis-related responses.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

IMD-1 is a potent dual inhibitor of acetylcholine and butyrylcholine esterases (AChE and BChE) with IC50 of 34.6 nM and 49.04 nM, protects SH-SY5Y cells against H2O2-induced oxidative injury by modulating oxidative stress, mitochondrial dysfunction, inflammatory mediator release, and apoptosis-related responses.

Physicochemical Properties

M.Wt 280.28
Formula C16H12N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-hydroxyphenyl) (4-(4-hydroxyphenyl)-1H-imidazole-2-yl) methanone

References

1. Burak Kuzu, et al. Bioorg Chem. 2019 May:86:187-196.

2. Derya-Andeden M, et al. Neurochem Res. 2026 Aug 12;51(4):236.

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