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Chemical Structure : IMM-01
CAS No.: 218795-74-5
Catalog No.: PC-62427Not For Human Use, Lab Use Only.
IMM-01 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 140 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 100 mg | Get quote |
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IMM-01 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 140 nM.
IMM-01 sufficiently triggers actin assembly and microtubule stabilization, serum response factor-mediated gene expression, cell-cycle arrest, and apoptosis in vitro.
IMM-01 slows tumor growth in a mouse xenograft model of colon cancer.
| M.Wt | 267.347 | |
| Formula | C12H17N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N1-(tert-butyl)-2-(2,4-dihydroxybenzylidene)hydrazine-1-carbothioamide |
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1. Lash LL, et al. Cancer Res. 2013 Nov 15;73(22):6793-803.
2. Arden JD, et al. Mol Biol Cell. 2015 Nov 1;26(21):3704-18.
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