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Chemical Structure : IMM-02
Catalog No.: PC-62428Not For Human Use, Lab Use Only.
IMM-02 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 99 nM.
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IMM-02 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 99 nM; sufficiently triggers actin assembly and microtubule stabilization, serum response factor-mediated gene expression, cell-cycle arrest, and apoptosis in vitro; slows tumor growth in a mouse xenograft model of colon cancer.
| M.Wt | 301.356 | |
| Formula | C13H17F2N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lash LL, et al. Cancer Res. 2013 Nov 15;73(22):6793-803.
2. Arden JD, et al. Mol Biol Cell. 2015 Nov 1;26(21):3704-18.
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