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Chemical Structure : IMT1B
CAS No.: 2304621-06-3
Catalog No.: PC-72917Not For Human Use, Lab Use Only.
IMT1B (LDC203974) a first-in-class specific inhibitor of mitochondrial transcription that target the human mitochondrial RNA polymerase (POLRMT)..
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | $798 | In stock | |
| 1 g | Get quote |
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IMT1B (LDC203974) a first-in-class specific inhibitor of mitochondrial transcription that target the human mitochondrial RNA polymerase (POLRMT).
IMT1B exhibits antiproliferative activity in A2780 cells with IC50 of 138 nM.
IMT1B is well-tolerated in mice, and suitable for in vivo use.
IMT1B does not cause OXPHOS dysfunction or toxicity in normal tissues, despite inducing a strong anti-tumour response in xenografts of human cancer cells.
| M.Wt | 473.88 | |
| Formula | C24H21ClFNO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO (4.74 mg/mL) |
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| Chemical Name/SMILES |
(S)-1-((R)-2-((4-(2-chloro-4-fluorophenyl)-2-oxo-2H-chromen-7-yl)oxy)propanoyl)piperidine-3-carboxylic acid |
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1. Bonekamp NA, et al. Nature. 2020 Dec;588(7839):712-716.
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