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Chemical Structure : INI-60
Catalog No.: PC-72017Not For Human Use, Lab Use Only.
INI-60 (Inhibitor of Nuclear Import-60) is a novel small molecule inhibitor of Kpnβ1-mediated nuclear import with anti-cancer activity.
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INI-60 (Inhibitor of Nuclear Import-60) is a novel small molecule inhibitor of Kpnβ1-mediated nuclear import with anti-cancer activity.
INI-60 treatment resulted in the inhibition of cancer cell proliferation, colony formation, migration and invasion, and induced a G1/S cell cycle arrest, followed by cancer cell death via apoptosis.
INI-60 treatment altered the localisation of Kpnβ1 and its cargoes, NFκB/p65, NFAT and AP-1, and the overexpression of Kpnβ1 reduced INI-60 cytotoxicity.
INI-60 also inhibited KYSE 30 oesophageal cancer cell line growth in vivo.
| M.Wt | 477.667 | |
| Formula | C28H35N3O2S | |
| Appearance | Solid | |
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1. Ajayi-Smith A, et al. Exp Cell Res. 2021 Jul 15;404(2):112637.
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