Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : INX-08189
CAS No.: 1234490-83-5
Catalog No.: PC-60009Not For Human Use, Lab Use Only.
INX-08189 (BMS-986094) is a phosphoramidate prodrug of O-6-methyl-2-C-methyl guanosine, potent inhibitor of HCV NS5B polymerase with IC50 of 10 nM in replicon assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
INX-08189 (BMS-986094) is a phosphoramidate prodrug of O-6-methyl-2-C-methyl guanosine, potent inhibitor of HCV NS5B polymerase with IC50 of 10 nM in replicon assay.
INX-08189 (BMS-986094) inhibits viral replication with EC50 of 35 nM, inhibits mutant NS5b S282T mutant replicon with EC90 of 344 nM; orally active.
| M.Wt | 658.649 | |
| Formula | C30H39N6O9P | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Neopentyl ((((2R,3R,4R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphoryl)-L-alaninate |
|
1. McGuigan C, et al. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4850-4.
2. Vernachio JH, et al. Antimicrob Agents Chemother. 2011 May;55(5):1843-51.
3. Ehteshami M, et al. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4659-69.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
