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Chemical Structure : IODVA1
Catalog No.: PC-38152Not For Human Use, Lab Use Only.
IODVA1 is a small molecule with cellular inhibitory activity against several transformed cell lines including Ras-driven cells, targets Rac activation and signaling instead of Ras.
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IODVA1 is a small molecule with cellular inhibitory activity against several transformed cell lines including Ras-driven cells, targets Rac activation and signaling instead of Ras.
IODVA1 inhibits ST8814 cell proliferation with GI50 of 1 uM, similar results were observed with MCF7, MDA-MB-231, and T47D cells with estimated GI50s <1 uM.
IODVA1 significantly decreases number of colonies of the breast cancer cells in soft agar at 1 and 3 uM.
IODVA1 probably does not bind Ras and that its mechanism of action is likely Ras-independent, inhibits lamellipodia and circular dorsal ruffle (CDR) formation in MDA-MB-231 cells and decreases Rac activation.
IODVA1 inhibits Rac activation and downstream signaling leading to inhibition of lamellipodia and CDR formation.
IODVA1 inhibits cell-substratum and cell-cell interactions, does not target kinases, and reduces tumor burden of solid tumors in vivo.
| M.Wt | 369.388 | |
| Formula | C20H15N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gasilina A, et al. PLoS One. 2020 Mar 12;15(3):e0229801.
2. Hegde S, et al. Leukemia. 2021 Oct 28. doi: 10.1038/s41375-021-01455-3.
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