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Chemical Structure : IOI-214
Catalog No.: PC-21466Not For Human Use, Lab Use Only.
IOI-214 is a potent inhibitor of LPS-induced inflammatory cytokine production, prevent HF diet-induced NAFLD/MAFLD in vivo.
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IOI-214 is a potent inhibitor of LPS-induced inflammatory cytokine production, prevent HF diet-induced NAFLD/MAFLD in vivo.
IOI-214 prevents LPS-induced inflammation in murine macrophages and hepatocytes in culture.
IOI-214 potently attenuates the robust LPS-induced upregulation of proinflammatory cytokine gene expression (Tnf, Ifnb1, Ccl2, Il1b, and Il6) in the cultured murine macrophages.
IOI-214 blocks HF diet-induced mesenteric fat accumulation without affecting HF diet-induced weight gain or subcutaneous fat accumulation.
IOI-214 (1 mg/kg, i.p.) ameliorates HF diet-induced hepatic steatosis.
IOI-214 mitigates HF diet-induced fasting hyperglycemia, without affecting fasting serum insulin, cholesterol or triglyceride levels, or glucose intolerance.
IOI-214 blocks HF diet-induced hepatic inflammatory cytokine and chemokine protein levels in vivo.
| M.Wt | 235.36 | |
| Formula | C12H13NS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kelly D McCall, et al. J Inflamm Res. 2023 Nov 16:16:5339-5366.
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