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Chemical Structure : IP6K1 inhibitor TNP
CAS No.: 519178-28-0
Catalog No.: PC-63313Not For Human Use, Lab Use Only.
IP6K1 inhibitor TNP is a potent, selective inositol hexakisphosphate kinase IP6K with IC50 of 0.47 uM (IP6K1), does not inhibit either human or yeast Vip/PPIP5K.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $478 | In stock | |
| 100 mg | Get quote |
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IP6K1 inhibitor TNP is a potent, selective inositol hexakisphosphate kinase IP6K with IC50 of 0.47 uM (IP6K1), does not inhibit either human or yeast Vip/PPIP5K.
IP6K1 inhibitor TNP reversibly inhibits InsP7 and InsP8 synthesis in vivo without affecting levels of other inositol phosphates.
IP6K1 inhibitor TNP increases the IGF-1 elicited stimulation of T308 phosphorylation of Akt without influencing p-S473, combination of TNP (10 μM) and SB216763 (1 μM) virtually abolishes adipogenic differentiation of NIH3T3-L1 cells.
IP6K1 inhibitor TNP ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway.
IP6K1 inhibitor TNP also suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia.
| M.Wt | 443.39 | |
| Formula | C20H16F3N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N6-(4-nitrobenzyl)-N2-(3-(trifluoromethyl)benzyl)-1H-purine-2,6-diamine |
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1. Ghoshal S, et al. Mol Metab. 2016 Aug 21;5(10):903-17.
2. Zhu Q, et al. J Clin Invest. 2016 Nov 1;126(11):4273-4288.
3. Padmanabhan U, et al. J Biol Chem. 2009 Apr 17;284(16):10571-82.
4. Chakraborty A, et al. Cell. 2010 Dec 10;143(6):897-910.
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