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Chemical Structure : IPI-549
CAS No.: 1693758-51-8
Catalog No.: PC-42233Not For Human Use, Lab Use Only.
Eganelisib (IPI-549) is a potent, highly selective, orally active inhibitor of PI3Kγ with IC50 of 16 nM, displays >100-fold selectivity over other lipid and protein kinases (PI3Kα IC50=3.2 uM, PI3Kβ IC50=3.5 uM, PI3Kδ IC50>8.4 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $478 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Eganelisib (IPI-549) is a potent, highly selective, orally active inhibitor of PI3Kγ with IC50 of 16 nM, displays >100-fold selectivity over other lipid and protein kinases (PI3Kα IC50=3.2 uM, PI3Kβ IC50=3.5 uM, PI3Kδ IC50>8.4 uM).
Eganelisib (IPI-549) demonstrates excellent PI3Kγ potency (IC50=1.2 nM) and selectivity against other Class I PI3K isoforms (>146-fold) in cellular phospho-AKT assays, dose dependently inhibits PI3Kγ dependent bone marrow-derived macrophage (BMDM) migration.
Eganelisib (IPI-549) demonstrates favorable pharmacokinetic properties and robust inhibition of PI3K-γ mediated neutrophil migration in vivo.
| M.Wt | 528.564 | |
| Formula | C30H24N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 15 mg/mL |
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| Chemical Name/SMILES |
Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[(1S)-1-[1,2-dihydro-8-[2-(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-3-isoquinolinyl]ethyl]- |
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1. Evans CA, et al. ACS Med Chem Lett. 2016 Jul 22;7(9):862-7.
2. De Henau O, et al. Nature. 2016 Nov 17;539(7629):443-447.
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