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Chemical Structure : IQM-266
Catalog No.: PC-36155Not For Human Use, Lab Use Only.
IQM-266 (IQM266) is a DREAM (Downstream Regulatory Element Antagonist Modulator) ligand (Kd=4.63 uM), inhibits the KV4.3/DREAM current in a concentration-, voltage-, and time-dependent-manner.
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IQM-266 (IQM266) is a DREAM (Downstream Regulatory Element Antagonist Modulator) ligand (Kd=4.63 uM), inhibits the KV4.3/DREAM current in a concentration-, voltage-, and time-dependent-manner.
IQM-266 is a new activator of the DREAM-mediated KV4.3 currents, decreases the peak current and slowing the inactivation kinetics, increases the transmembrane charge (QKV4.3/DREAM ) at a certain range of concentrations.
IQM-266 inhibits the peak amplitude and slowed the inactivation of I A in rat dorsal root ganglion neurons.
IQM-266 is a new chemical tool that might allow a better understanding of DREAM physiological role as well as modulation of neuronal I A in pathological processes.
| M.Wt | 397.43 | |
| Formula | C25H19NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Peraza DA, et al. Front Mol Neurosci. 2019 Feb 4;12:11. doi: 10.3389/fnmol.2019.00011.
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