Chemical Structure : IR-546
CAS No.:
IR-546
(IR546)
Catalog No.: PC-24905Not For Human Use, Lab Use Only.
IR-546 is a NIR fluorescent probe, inhibits melanoma cell proliferation by activating the mitochondrial apoptosis pathway through suppression of the AKT/GSK3β signaling pathway.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IR-546 is a NIR fluorescent probe, inhibits melanoma cell proliferation by activating the mitochondrial apoptosis pathway through suppression of the AKT/GSK3β signaling pathway.
IR-546 exhibits an absorption peak at 600 nm, and an emission peak at 605 nm and 650 nm, confirming its near-infrared (NIR) fluorescence properties (600–900 nm).
IR-546 exhibits cell-killing effect on melanoma cellsin vitro and in vivo.
IR-546 shows MTT IC50 of 2.4, 0.7, and 0.2 µM for A375 melanoma cells at 24 h, 48 h, and 72 h, respectively, and for B16-F10 melanoma cells is 4.3, 1.7, and 1.0 µM, respectively.
IR-546 induces apoptosis of melanoma cells by affecting mitochondrial function.
IR-546 inhibits the metastasis of A375 and B16-F10 melanoma cells.
IR-546 inhibits the growth of melanoma without obvious side effects in vivo.
Physicochemical Properties
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M.Wt
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748.72
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Formula
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C41H37IN2O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-2-(2-(5-(4-(bis(4-methoxyphenyl)amino)phenyl)thiophen-2-yl)vinyl)-1,1,3-trimethyl-1H-benzo[e]indol-3-ium iodide
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References
1. Hongye Liao, et al. Mol Med. 2025 Jun 10;31(1):226.
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