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Chemical Structure : IRF5 inhibitor N5-1
CAS No.: 2088834-66-4
Catalog No.: PC-72047Not For Human Use, Lab Use Only.
IRF5 inhibitor N5-1 (PRRVRLK) is a cell permeable, IRF5 peptide mimetic that selectively bind to and stabilizes the inactive IRF5 monomer with KD of 98.8 nM.
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|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $328 | In stock | |
| 25 mg | $548 | In stock | |
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IRF5 inhibitor N5-1 (PRRVRLK) is a cell permeable, IRF5 peptide mimetic that selectively bind to and stabilizes the inactive IRF5 monomer with KD of 98.8 nM.
IRF5 inhibitor N5-1 binds to endogenous IRF5, but not IRF3 or IRF7, in human primary monocytes.
IRF5 inhibitor N5-1 significantly reduced R848-induced IRF5 nuclear translocation in monocytes.
IRF5 inhibitor N5-1 binds to the C-terminal IAD of inactive IRF5 monomer and inhibits phosphorylation of Ser462, readily enters primary immune cells to inhibit R848-induced IRF5 nuclear translocation with low associated toxicity.
IRF5 inhibitor N5-1 is a potent inhibitor of TLR7-induced IRF5 nuclear translocation in monocytes and B cells, selectively inhibits IRF5-mediated inflammatory cytokine expression in PBMCs.
IRF5 inhibitor N5-1 attenuated IL-6 production and IRF5 hyperactivation in NZB/W F1 mice, and reducedkidney pathology and increased overall survival in NZB/W F1 mice from spontaneous onset of lupus and mortality.
| M.Wt | 924.15 | |
| Formula | C40H77N17O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
L-Prolyl-L-arginyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-lysine |
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1. Su Song, et al. J Clin Invest. 2020 Dec 1;130(12):6700-6717.
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