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Chemical Structure : ISA27
Catalog No.: PC-62500Not For Human Use, Lab Use Only.
ISA27 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.
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ISA27 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.
ISA27 reduces cell proliferation and induces apoptosis in vitro in cells carrying either p53 WT or mutated gene, suggesting that its effect is independent from p53 transcriptional activity.
ISA27 induces cancer cell death in a dose-dependent manner through the activation of the mitochondrial-dependent death signalling in p53-mutated cells.
| M.Wt | 399.849 | |
| Formula | C19H14ClN3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sorriento D, et al. Br J Cancer. 2015 Jan 6;112(1):77-85.
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