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Chemical Structure : ISO-1
CAS No.: 478336-92-4
Catalog No.: PC-45038Not For Human Use, Lab Use Only.
ISO-1 is a potent inhibitor of Migration inhibitory factor (MIF) tautomerase activity with IC50 of 7 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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ISO-1 is a potent inhibitor of Migration inhibitory factor (MIF) tautomerase activity with IC50 of 7 uM.
ISO-1 significantly inhibits the cytokine activity in vitro, inhibits TNF release from macrophages isolated from LPS-treated wild type mice but has no effect on cytokine release from MIF-deficient macrophages.
ISO-1 is the first small molecule inhibitor of MIF proinflammatory activities with therapeutic implications.
| M.Wt | 235.2359 | |
| Formula | C12H13NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 36 mg/mL |
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| Chemical Name/SMILES |
5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester |
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1. Lubetsky JB, et al. J Biol Chem. 2002 Jul 12;277(28):24976-82.
2. Al-Abed Y, et al. J Biol Chem. 2005 Nov 4;280(44):36541-4.
3. Adamali H, et al. Am J Respir Crit Care Med. 2012 Jul 15;186(2):162-9.
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