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Chemical Structure : ITYR-DBRMD
Catalog No.: PC-38163Not For Human Use, Lab Use Only.
ITYR-DBRMD is a first-in-class inhibitor of enzyme iodothyronine deiodinase type 3 (DIO3) with antitumor effects both in vitro and in vivo.
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ITYR-DBRMD is a first-in-class inhibitor of enzyme iodothyronine deiodinase type 3 (DIO3) with antitumor effects both in vitro and in vivo.
ITYR-DBRMD demonstrated attenuated cell counts, induction in apoptosis, and a reduction in cell proliferation in DIO3-positive HGSOC cells (OVCAR3 and KURAMOCHI), but not in DIO3-negative normal ovary cells (CHOK1) and OVCAR3 depleted for DIO3 or its substrate, T3.
| M.Wt | 670.818 | |
| Formula | C13H7Br2I2NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dotan Moskovich, et al. Oncogene. 2021 Nov;40(44):6248-6257.
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