Catalog No.: PC-23494Not For Human Use, Lab Use Only.
Ibetazol is novel specific small molecule inhibitor of importin β1 (KPNB1)-mediated nuclear import with EC50 of 6.3 uM in phenotypic importin α1 translocation assays , binds to cysteine 585 of importin β1.
Ibetazol is novel specific small molecule inhibitor of importin β1 (KPNB1)-mediated nuclear import with EC50 of 6.3 uM in phenotypic importin α1 translocation assays , binds to cysteine 585 of importin β1.
Ibetazol interacts with cysteine 585 in importin β1, and thereby effectively prohibits both direct and adaptor (importin α) protein-dependent importin β1-mediated nuclear import.
Ibetazol has EC50 of 6.3 uM in phenotypic importin α1 translocation assays, with no cytotoxicity in HEK293T cells.
Ibetazol specifically inhibit importin β1-dependent import (the direct importin β1 dependent cargo SREBP1, importin α1, and importin β1-importin α cargos).
