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Icariin

Chemical Structure : Icariin

CAS No.: 489-32-7

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Icariin

Catalog No.: PC-25743Not For Human Use, Lab Use Only.

Icariin is a flavonol glycoside that inhibits PDE5 and PDE4 activities with IC50 of 432 nM and 73.50 μM, respectively, also is a PPARα activator, also is a small-molecule inducer that promotes G3BP1-driven biomolecular condensate formation, interacts with the N-terminal nuclear transport factor 2-like (NTF2L) domain of G3BP1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Icariin is a flavonol glycoside that inhibits PDE5 and PDE4 activities with IC50 of 432 nM and 73.50 μM, respectively, also is a PPARα activator, also is a small-molecule inducer that promotes G3BP1-driven biomolecular condensate formation, interacts with the N-terminal nuclear transport factor 2-like (NTF2L) domain of G3BP1.

Physicochemical Properties

M.Wt 676.67
Formula C33H40O15
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-Hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

References

1. Xin ZC, et al. Asian J Androl. 2003 Mar;5(1):15-8.

2. Lu YF, et al. Molecules. 2014 Nov 6;19(11):18179-91.

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