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Icosabutate

Chemical Structure : Icosabutate

CAS No.: 1253909-57-7

Icosabutate

Catalog No.: PC-27329Not For Human Use, Lab Use Only.

Icosabutate is a dual FFAR1/FFAR4 (GPR40/GPR120) agonist with EC50 of 10 μM and 15.5 μM, respectively, also is a partial agonist of PPARα with EC50 of 208 nM, inhibits the arachidonic acid cascade and exhibits antioxidant and anti-apoptotic activities.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Icosabutate is a dual FFAR1/FFAR4 (GPR40/GPR120) agonist with EC50 of 10 μM and 15.5 μM, respectively, also is a partial agonist of PPARα with EC50 of 208 nM, inhibits the arachidonic acid cascade and exhibits antioxidant and anti-apoptotic activities.

Physicochemical Properties

M.Wt 374.57
Formula C24H38O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(((5Z,8Z,11Z,14Z,17Z)-Icosa-5,8,11,14,17-pentaen-1-yl)oxy)butanoic acid

References

1. Harrison SA, et al. J Hepatol. 2025 Aug;83(2):293-303.

2. Stokman G, et al. Liver Int. 2020 Nov;40(11):2860-2876.

3. van den Hoek AM, et al. Hepatol Commun. 2019 Dec 24;4(2):193-207.

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