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Chemical Structure : Icotinib
CAS No.: 610798-31-7
Catalog No.: PC-22087Not For Human Use, Lab Use Only.
Icotinib (BPI-2009) is a potent and specific EGFR inhibitor with IC50 of 5 nM, also inhibits mutant EGFRL858R, EGFR L858R/T790M, EGFR T790M and EGFR L861Q.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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Icotinib (BPI-2009) is a potent and specific EGFR inhibitor with IC50 of 5 nM, also inhibits mutant EGFRL858R, EGFR L858R/T790M, EGFR T790M and EGFR L861Q.
Icotinib only shows meaningful inhibitory activity to EGFR and its mutants against a panel of 88 kinases.
Icotinib blocks EGFR-mediated intracellular tyrosine phosphorylation (IC(50)=45 nM) in the human epidermoid carcinoma A431 cell line and inhibits tumor cell proliferation.
Icotinib exhibits potent dose-dependent antitumor effects in nude mice carrying a variety of human tumor-derived xenografts.
| M.Wt | 391.43 | |
| Formula | C22H21N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(3-Ethynylphenyl)-7,8,10,11,13,14-hexahydro-[1,4,7,10]tetraoxacyclododecino[2,3-g]quinazolin-4-amine |
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1. Tan F, et al. Lung Cancer. 2012 May;76(2):177-82.
2. Yang G, et al. Oncol Rep. 2012 Jun;27(6):2066-72.
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