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Chemical Structure : Idalopirdine hydrochloride
CAS No.: 467458-02-2
Catalog No.: PC-21670Not For Human Use, Lab Use Only.
Idalopirdine (Lu AE58054) is a potent, selective 5-HT6 receptor antagonist with Ki of 0.83 nM.
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|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $288 | In stock | |
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Idalopirdine (Lu AE58054) is a potent, selective 5-HT6 receptor antagonist with Ki of 0.83 nM.
Idalopirdine (Lu AE58054) shows no agonist activity in 5-HT(6) GTPgammaS efficacy assay.
Idalopirdine (Lu AE58054) demonstrates >50-fold selectivity for >70 targets.
Idalopirdine (Lu AE58054) potently inhibits striatal in-vivo binding of the 5-HT(6) antagonist radioligand [(3)H]Lu AE60157 ([(3)H]8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline), with an ED(50) of 2.7 mg/kg.
Idalopirdine (Lu AE58054) exhibits good oral bioavailability and robust efficacy in a rat model of cognitive impairment in schizophrenia.
| M.Wt | 434.84 | |
| Formula | C20H20ClF5N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(6-Fluoro-1H-indol-3-yl)-N-(3-(2,2,3,3-tetrafluoropropoxy)benzyl)ethanamine hydrochloride |
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1. Arnt J, et al. Int J Neuropsychopharmacol. 2010 Sep;13(8):1021-33.
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