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Chemical Structure : Idarubicin hydrochloride
CAS No.: 57852-57-0
Catalog No.: PC-45203Not For Human Use, Lab Use Only.
Idarubicin hydrochloride (4-Demethoxydaunorubicin) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $118 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | Get quote |
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Idarubicin hydrochloride (4-Demethoxydaunorubicin) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells.
Idarubicin inhibits the proliferation of MCF-7 cells with IC50 of 0.1 uM.
Idarubicin also induces histone eviction from chromatin.
| M.Wt | 533.9548 | |
| Formula | C26H28ClNO9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5,12-Naphthacenedione, 9-acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, hydrochloride (1:1), (7S,9S)- |
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1. Gewirtz DA, et al. Cancer Chemother Pharmacol. 1998;41(5):361-9.
2. Pang B, et al. Nat Commun. 2013;4:1908.
3. Nitiss JL. Nat Rev Cancer. 2009 May;9(5):338-50.
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