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Chemical Structure : Imirestat
CAS No.: 89391-50-4
Catalog No.: PC-20625Not For Human Use, Lab Use Only.
Imirestat (AL-1576) is a potent aldose reductase inhibitor with IC50 of 8.5 nM for rat lens aldose reductase, with similar IC50 value for the human placental enzyme, shows high affinity for AKR1A1 and AKR1B1 with Ki of 47 and 46 nM respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | $758 | In stock | |
| 1 g | Get quote |
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Imirestat (AL-1576) is a potent aldose reductase inhibitor with IC50 of 8.5 nM for rat lens aldose reductase, with similar IC50 value for the human placental enzyme, shows high affinity for AKR1A1 and AKR1B1 with Ki of 47 and 46 nM respectively.
Imirestat (AL-1576) prevents significantly the decrease of norepinephrine (NE) turnover in three tissues of streptozotocin (STZ)-diabetic rats.
| M.Wt | 286.24 | |
| Formula | C15H8F2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,7-difluorospiro[fluorene-9,4'-imidazolidine]-2',5'-dione |
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1. T T Yen, et al. Res Commun Chem Pathol Pharmacol. 1988 Aug;61(2):257-60.
2. Griffin BW, et al. Metabolism. 1987 May;36(5):486-90.
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