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Cat. No. Product Name CAS No. Information
PC-62883

MK-204

1959605-73-2 MK-204 is a potent, selective AKR1B10 inhibitor with IC50 of 80 nM, shows high selective (270-fold) over AKR1B1; a lead compound targeting the distinct AKR1B10 specificity pocket and with a strong X-bond.
PC-62882

IDD388

314297-26-2 IDD388 is a potent aldose reductase (ALR2 or AKR1B1) inhibitor with IC50 of 0.4 uM, shows weak inhibition for AKR1B10 (IC50=4.4 uM).
PC-61992

Fidarestat

136087-85-9 Fidarestat (SNK860) is a potent aldose reductase inhibitor, improves motor nerve conduction velocity (MNCV) and metabolic abnormalities in sciatic nerve were investigated in acute STZ-induced diabetic rats.

Diabetes

Phase 3 Discontinued

PC-45580

Aldose reductase-IN-1

1355612-71-3 An inhibitor of aldose reductase with IC50 of 28.9 pM; extracted from Patent WO2014113380 A1 and US20130225592.
PC-45922

Epalrestat

82159-09-9 A noncompetitive and reversible aldose reductase inhibitor with IC50 of 10 nM and 26 nM for purified aldose reductase from rat lens and human placenta, respectively; used for the treatment of diabetic neuropathy.

Diabetes

Approved

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