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Chemical Structure : Inauhzin
CAS No.: 309271-94-1
Catalog No.: PC-38473Not For Human Use, Lab Use Only.
Inauhzin (INZ) is a small molecule SIRT1 inhibitor that effectively reactivates p53, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $348 | In stock | |
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| 1 g | Get quote |
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Inauhzin (INZ) is a small molecule SIRT1 inhibitor that effectively reactivates p53, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress.
Inauhzin (INZ) induced p53 levels as effectively as actinomycin D (ActD, 10 nM), did not apparently affect the interaction between either MDMX and p53, or MDM2 and MDMX, or MDM2 and p53.
Inauhzin inhibited cell growth in a p53-dependent fashion against human lung cancer H460, A549, H1299, colon cancer HCT116, HT29 (IC50=5-50 uM), induceed p53 level and activity as well as p53-dependent apoptosis.
Inauhzin (INZ) stabilizes p53 without either directly inhibiting MDM2-mediated ubiquitylation or causing genotoxicity.
Inauhzin (INZ) effectively inhibits SIRT1 deacetylase activity at 3 uM, directly binds to SIRT1 in vitro, induces p53 acetylation at lysine 382 at 2 uM in cells.
Inauhzin (INZ) induces p53 and p53-dependent apoptosis in vivo and suppresses the growth of human xenograft tumours.
| M.Wt | 469.581 | |
| Formula | C25H19N5OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-1-(10H-phenothiazin-10-yl)butan-1-one |
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1. Zhang Q, et al. EMBO Mol Med. 2012 Apr;4(4):298-312.
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