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Indotecan

Chemical Structure : Indotecan

CAS No.: 915303-09-2

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Indotecan (LMP400;LMP-400)

Catalog No.: PC-63536Not For Human Use, Lab Use Only.

Indotecan (LMP400) is an anticancer DNA Topoisomerase I (Top1) inhibitor, inhibits P388, HCT116, MCF-7 cell lines with IC50 of 300, 1200, 560 nM respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Indotecan (LMP400) is an anticancer DNA Topoisomerase I (Top1) inhibitor, inhibits P388, HCT116, MCF-7 cell lines with IC50 of 300, 1200, 560 nM respectively.

Physicochemical Properties

M.Wt 478.501
Formula C26H26N2O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,3-Dimethoxy-6-[3-(4-morpholinyl)propyl]-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione

References

1. Cinelli MA, et al. J Med Chem. 2012 Dec 27;55(24):10844-62.

2. Maede Y, et al. Mol Cancer Ther. 2014 Jan;13(1):214-20.

3. Beck DE, et al. J Med Chem. 2014 Feb 27;57(4):1495-512.

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