Catalog No.: PC-27596Not For Human Use, Lab Use Only.
Isofagomine (Afegostat) is a broad spectrum inhibitor of glycosidases, inhibits beta-glucosidase, glucoamylase, isomaltase, and alpha-glucosidase, specifically and reversibly binds lysosomal hydrolase acid β-glucosidase (GCase) in the ER with high affinity.
Isofagomine (Afegostat) is a broad spectrum inhibitor of glycosidases, inhibits beta-glucosidase, glucoamylase, isomaltase, and alpha-glucosidase, specifically and reversibly binds lysosomal hydrolase acid β-glucosidase (GCase) in the ER with high affinity.
Isofagomine (Afegostat) stabilizes the active form of GCase in the ER and increases trafficking of GCase to lysosomes.
Isofagomine (Afegostat) improved motor and nonmotor function, abolished microglial inflammatory response in the substantia nigra, reduced α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduced the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates.
Physicochemical Properties
M.Wt
147.17
Formula
C6H13NO3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol
References
1. Dong W, et al. Biochemistry. 1996 Feb 27;35(8):2788-95.
2. Waagepetersen HS, et al. Neurochem Int. 2000 Apr;36(4-5):435-40.
3. Richter F, et al. Neurotherapeutics. 2014 Oct;11(4):840-56.
