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Isomigrastatin

Chemical Structure : Isomigrastatin

CAS No.: 415952-70-4

Isomigrastatin (iso-Migrastatin)

Catalog No.: PC-62237Not For Human Use, Lab Use Only.

Isomigrastatin (iso-Migrastatin) is an analogue of migrastatin that shows potent antiproliferative effect on tumor cell lines and selectively inhibits translation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Isomigrastatin (iso-Migrastatin) is an analogue of migrastatin that shows potent antiproliferative effect on tumor cell lines and selectively inhibits translation; inhibits the migration of human metastatic breast cancer cells, prostate cancer cells, and colon cancer cells but not normal mammary-gland epithelial cells, fibroblasts, and leukocytes.

Physicochemical Properties

M.Wt 489.609
Formula C27H39NO7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-[(E,5S)-7-[(2R,3S,4S,5S,6E,10E)-4-hydroxy-5-methoxy-3-methyl-12-oxo-1-oxacyclododeca-6,10-dien-2-yl]-5-methyl-4-oxooct-6-enyl]piperidine-2,6-dione

References

1. Schneider-Poetsch T, et al. Nat Chem Biol. 2010 Mar;6(3):209-217.

2. Shan D, et al. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3772-6.

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