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Ixabepilone

Chemical Structure : Ixabepilone

CAS No.: 219989-84-1

Ixabepilone (Azaepothilone B;BMS-247550;BMS247550)

Catalog No.: PC-42466Not For Human Use, Lab Use Only.

A semisynthetic Epothilone B analogue and potent, orally active microtubule stabilizer.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A semisynthetic Epothilone B analogue and potent, orally active microtubule stabilizer; shows a broad spectrum of activity against a panel of tumor cell lines in vitro (IC50=1.4-34.5 nM), retains the antineoplastic activity against human cancers that are resistance to paclitaxel both in vitro and in vivo.

Breast Cancer

Approved

Physicochemical Properties

M.Wt 506.6978
Formula C27H42N2O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

17-Oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (1S,3S,7S,10R,11S,12S,16R)-

References

1. Lee FY, et al. Clin Cancer Res. 2001 May;7(5):1429-37.

2. Yamaguchi H, et al. Cancer Res. 2002 Jan 15;62(2):466-71.

3. Peterson JK, et al. Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6950-8.

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