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JAB-3068

Chemical Structure : JAB-3068

CAS No.: 2169223-48-5

JAB-3068 (JAB3068)

Catalog No.: PC-20250Not For Human Use, Lab Use Only.

JAB-3068 (JAB3068) is a potent, selective and orally bioavailable allosteric inhibitor of SHP2 with IC50 of 25.8 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JAB-3068 (JAB3068) is a potent, selective and orally bioavailable allosteric inhibitor of SHP2 with IC50 of 25.8 nM.

Physicochemical Properties

M.Wt 476.54
Formula C22H26F2N6O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-[4-[[3-Amino-5-[(4S)-4-amino-2-oxa-8-azaspiro[4.5]dec-8-yl]-2-pyrazinyl]thio]-3,3-difluoro-2,3-dihydro-1H-indol-1-yl]ethanone

References

1. Patent WO2022135346 A1.

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