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Chemical Structure : JCN037
CAS No.: 2305154-31-6
Catalog No.: PC-38187Not For Human Use, Lab Use Only.
JCN037 (JCN 037, JGK037) is novel potent, brain-penetrant, noncovalent EGFR TKI with IC50 of 2.49 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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JCN037 (JCN 037, JGK037) is novel potent, brain-penetrant, noncovalent EGFR TKI with IC50 of 2.49 nM.
JCN037 demonstrated both nanomolar potency against both mutant EGFRvIII and wtEGFR in cellular assays (IC50=3.85 and 4.48 nM, respectively) and greater than 2:1 brain to plasma levels.
JCN037 shows high inhibitory activity against EGFRvIII mutant patient derived GBM cells, HK301 and GBM39, which is more potent than Erlotinib and Lapatinib.
JCN037 displays superior efficacy in an EGFR-driven orthotopic glioblastoma xenograft model.
| M.Wt | 376.185 | |
| Formula | C16H11BrFN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(3-bromo-2-fluorophenyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine |
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1. Jonathan E Tsang, et al. ACS Med Chem Lett. 2020 May 1;11(10):1799-1809.
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