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Chemical Structure : JH295
CAS No.: 1311143-71-1
Catalog No.: PC-20309Not For Human Use, Lab Use Only.
JH295 (JH-295) is a potent, selective and irreversible Nek2 kinase inhibitor with IC50 of 770 nM, inhibits Nek2 via alkylation of residue Cys22, does not inhibit Cdk1/CycB (IC50>20 uM).
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JH295 (JH-295) is a potent, selective and irreversible Nek2 kinase inhibitor with IC50 of 770 nM, inhibits Nek2 via alkylation of residue Cys22, does not inhibit Cdk1/CycB (IC50>20 uM).
JH295 selectively and irreversibly inhibits cellular Nek2 without affecting the mitotic kinases, Cdk1, Aurora B, or Plk1, does not perturb bipolar spindle assembly or the spindle assembly checkpoint.
JH295 inhibits cellular Nek2 in a Cys22-dependent manner, inhibits WT Nek2 in cells with IC50 of 1.6 uM in IP kinase assays, shows little effect on the C22V mutant.
JH295 does not perturb bipolar spindle assembly or chromosome congression.
| M.Wt | 320.35 | |
| Formula | C18H16N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[(3Z)-3-[(2-Ethyl-4-methyl-1H-imidazol-5-yl)methylene]-2,3-dihydro-2-oxo-1H-indol-5-yl]-2-propynamide |
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1. Henise JC, et al. J Med Chem. 2011 Jun 23;54(12):4133-46.
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