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Chemical Structure : JNJ-17203212
CAS No.: 821768-06-3
Catalog No.: PC-42062Not For Human Use, Lab Use Only.
A potent, selective and orally bioavailable TRPV1 receptor antagonist with IC50 of 65 nM and 102 nM for hTRPV1 and rTRPV1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $112 | In stock | |
| 25 mg | $240 | In stock | |
| 50 mg | $416 | In stock | |
| 100 mg | $736 | In stock |
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A potent, selective and orally bioavailable TRPV1 receptor antagonist with IC50 of 65 nM and 102 nM for hTRPV1 and rTRPV1, respectively; exhibits high selectivity against a panel of receptors and transporters, and does not inhibits related TRP channels TRPV2, TRPV4, or TRPA1; inhibits both pH (pIC50=7.23) and capsaicin (pIC50=6.32)-induced channel activation; attenuates capsaicin evoked coughs, prevents core hypothermia evoked by capsaicin in vivo.
Pain
Preclinical
| M.Wt | 419.3243 | |
| Formula | C17H15F6N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Piperazinecarboxamide, 4-[3-(trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]- |
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1. Swanson DM, et al. J Med Chem. 2005 Mar 24;48(6):1857-72.
2. Bhattacharya A, et al. J Pharmacol Exp Ther. 2007 Nov;323(2):665-74.
3. Cefalu JS, et al. J Urol. 2009 Aug;182(2):776-85.
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