Chemical Structure : JNJ-3792165
CAS No.:
353504-63-9
JNJ-3792165
(JNJ3792165)
Catalog No.: PC-26127Not For Human Use, Lab Use Only.
JNJ-3792165 is a potent and selective antagonist at GPR139 with high affinity for human GPR139 (pKi =7.7, displacement of [3H] JNJ-6353054), behaves as an antagonist in [35S]GTPγS assay (pKb=7.4) and calcium mobilization assay.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JNJ-3792165 is a potent and selective antagonist at GPR139 with high affinity for human GPR139 (pKi =7.7, displacement of [3H] JNJ-6353054), behaves as an antagonist in [35S]GTPγS assay (pKb=7.4) and calcium mobilization assay.
JNJ-3792165 displayed no significant affinity in a selectivity screen of over 50 other neurotransmitter and neuropeptide receptors at 1 uM.
JNJ-3792165 (10 uM) Completely blocks the effects of optogenetic stimulation of dynorphin release in dynorphinergic neurons of the nucleus accumbens at 10 uM.
Physicochemical Properties
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M.Wt
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374.27
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Formula
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C19H17Cl2N3O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(2,6-Dichlorobenzyl)-5-methyl-N-(m-tolyl)-1H-pyrazole-3-carboxamide
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References
1. Nepomuceno D, et al. Front Pharmacol 2018;9:157.
2. Xiaona Li, et al. Nat Commun. 2025 Jul 23;16(1):6786.
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