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Chemical Structure : JNJ303
CAS No.: 878489-28-2
Catalog No.: PC-63222Not For Human Use, Lab Use Only.
JNJ303 is a potent, specific delayed rectifier potassium current I(Ks) blocker with IC50 of 64 nM, shows no effects on other cardiac channels (IC50=3.3, >10, 11.1 and 12.6 uM for Na, ICa, Ito and IKr currents).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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JNJ303 is a potent, specific delayed rectifier potassium current (IKs) blocker with IC50 of 64 nM, shows no effects on other cardiac channels (IC50=3.3, >10, 11.1 and 12.6 uM for Na, ICa, Ito and IKr currents).
JNJ303 prolongs QT, strongly increases field potential (FP) duration.
| M.Wt | 440.983 | |
| Formula | C21H29ClN2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide |
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1. Wrobel E, et al. Nat Commun. 2016 Oct 12;7:12795.
2. Braam SR, et al. Stem Cell Res. 2013 Jan;10(1):48-56.
4. Guns PJ, et al. J Pharmacol Toxicol Methods. 2012 Sep;66(2):125-34.
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