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Chemical Structure : JNJ 41876666
Catalog No.: PC-60719Not For Human Use, Lab Use Only.
A potent, selective, orally active TRPM8 channel antaognist with IC50 of 0.8 nM, .
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A potent, selective, orally active TRPM8 channel antaognist with IC50 of 0.8 nM, ; exhibits minimal effect on the enzyme activity of CYP isoforms 3A4, 1A2, 2D6, 2C9, and 2C19 (IC50>10 uM); completely prevents icilin-induced WDS at an oral dose of 10 mg/kg, exhibits potent in vitro functional activity and robust oral efficacy in an inflammatory model of neuropathic pain at relatively low plasma levels; also reduces proliferation rates and proliferative fraction in prostate cancer cells.
| M.Wt | 503.873 | |
| Formula | C23H20ClF6N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Valero ML, et al. PLoS One. 2012;7(12):e51825.
2. Parks DJ, et al. J Med Chem. 2011 Jan 13;54(1):233-47.
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