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Chemical Structure : JP-11646
CAS No.: 1902983-63-4
Catalog No.: PC-63142Not For Human Use, Lab Use Only.
JP-11646 is a novel potent, selective, non-ATP competitive Pim2 inhibitor with IC50 of 0.5/1/24 nM for Pim2/3/1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $258 | In stock | |
| 5 mg | $458 | In stock | |
| 10 mg | $728 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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JP-11646 (JP11646) is a novel potent, selective, non-ATP competitive Pim2 inhibitor with IC50 of 0.5/1/24 nM for Pim2/3/1, respectively.
JP-11646 shows less potency for other kinases in a kinase selectivity panel.
JP-11646 exhibits 4-760-fold greater suppression of MM proliferation and viability than ATP-competitive PIM inhibitors.
JP-11646 significant reduces tumor burden and increases median survival in xenogeneic myeloma murine models.
| M.Wt | 459.568 | |
| Formula | C25H25N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-5-((2-(((1r,4r)-4-((naphthalen-1-ylmethyl)amino)cyclohexyl)amino)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione |
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1. Nair JR, et al. Leukemia. 2017 Aug;31(8):1715-1726.
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