Chemical Structure : JPC0661
CAS No.:
30479-81-3
JPC0661
(JPC-0661)
Catalog No.: PC-25797Not For Human Use, Lab Use Only.
JPC0661 is a specific small molecule direct inhibitor of AP1 transcription factor ΔdeltaFOSB (ΔFOSB), inhibits FOSB/JUND and ΔFOSB DNA-binding biochemically with IC50 of 9 uM and 52 uM respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JPC0661 is a specific small molecule direct inhibitor of AP1 transcription factor ΔdeltaFOSB (ΔFOSB), inhibits FOSB/JUND and ΔFOSB DNA-binding biochemically with IC50 of 9 uM and 52 uM respectively.
JPC0661 inhibits ΔFOSB-mediated transcription in cell-based assays with IC50 of 0.2 uM in luciferase reporter assays.
JPC0661 binds to a groove outside of the DNA-binding cleft of the ΔFOSB/JUND bZIP heterodimer.
JPC0661 disrupts DNA-binding directly, inhibits the ability of ΔFOSB to promote gene expression in cultured cells.
JPC0661 directly disrupts ΔFOSB–DNA interactions in vivo, inhibits ΔFOSB binding to AP1 consensus DNA-binding sites in vivo in an APP mouse model of AD neuropathology.
Physicochemical Properties
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M.Wt
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347.35
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Formula
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C15H13N3O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-(3-amino-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)-2-phenoxybenzenesulfonic acid
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References
1. McNeme S, et al. bioRxiv [Preprint]. 2025 Oct 23:2025.10.21.683675.
2. McNeme S, et al. bioRxiv [Preprint]. 2025 Oct 23:2025.10.21.683721.
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