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Chemical Structure : JTE-852
Catalog No.: PC-63130Not For Human Use, Lab Use Only.
JTE-852 is a novel potent, selective, ATP-competitive Syk kinase inhibitor with IC50 of 1.25/1.28 nM for human/rat Syk, respectively.
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JTE-852 is a novel potent, selective, ATP-competitive Syk kinase inhibitor with IC50 of 1.25/1.28 nM for human/rat Syk, respectively.
JTE-852 is less potent for Lck (IC50=80 nM), and has IC50 of >300 nM against a kinase panel screenings;.
JTE-852 inhibits the kinase activity of Syk in an intracellular condition, suppresses the secretion of histamine, LTC4/D4/E4, TXA2, PGD2, and IL-13 from mast cells stimulated by IgE-crosslinking with IC50 of 40-100 nM.
JTE-852 attenuates IgG-mediated responses and signs in animal model of autoimmune diseases.
| M.Wt | 437.562 | |
| Formula | C23H27N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kato T, et al. Eur J Pharmacol. 2017 Apr 15;801:1-8.
2. Kato T, et al. Life Sci. 2017 Dec 15;191:166-174.
3. Kato T, et al. J Vet Med Sci. 2018 Jan 26. doi: 10.1292/jvms.17-0659.
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