Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : JTE 013
CAS No.: 547756-93-4
Catalog No.: PC-60745Not For Human Use, Lab Use Only.
JTE-013 (JTE013) is a potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 17 nM and 22 nM for human and rat S1P2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
JTE-013 (JTE013) is a potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 17 nM and 22 nM for human and rat S1P2, respectively.
JTE-013 does not affect S1P binding to S1P3 and S1P1 at 10 uM.
JTE-013 inhibits not only S1P-induced vasoconstriction, but also KCl-, U46619- and endothelin-1-induced constriction in vivo.
JTE-013 abrogates S1P induced inhibition and activation, respectively, of Rac and RhoA in B16 cells.
| M.Wt | 408.29 | |
| Formula | C17H19N7OCl2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide |
|
1. Li MH, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):261-8.
2. Ohmori T, et al. Cardiovasc Res. 2003 Apr 1;58(1):170-7.
3. Arikawa K, et al. J Biol Chem. 2003 Aug 29;278(35):32841-51.
4. Ohmori T, et al. J Thromb Haemost. 2004 Jan;2(1):203-5.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
