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Chemical Structure : JTT-551 sodium
Catalog No.: PC-35559Not For Human Use, Lab Use Only.
JTT-551 sodium (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR.
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JTT-551 sodium (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR.
JTT-551 exhibits clear selectivity against the other PTPs, increases the insulin-stimulated glucose uptake in L6 cells.
JTT-551 enhances the IR phosphorylation of liver and reduces the glucose level in ob/ob mice.
JTT-551 also shows a hypoglycaemic effect without an acceleration of body weight gain in db/db mice.
| M.Wt | 628.846 | |
| Formula | C34H43N3NaO3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fukuda S, et al. Diabetes Obes Metab. 2010 Apr;12(4):299-306.
2. Ito M, et al. J Diabetes Res. 2014;2014:680348.
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