Chemical Structure : JWJ-01-306
CAS No.:
3069975-17-0
JWJ-01-306
Catalog No.: PC-25325Not For Human Use, Lab Use Only.
JWJ-01-306 is a potent and selective molecular glue degrader of transcription factor ZBTB11 with DC50 of 620 nM, Dmax, 10 µM of 80%, in MIA PaCa-2 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JWJ-01-306 is a potent and selective molecular glue degrader of transcription factor ZBTB11 with DC50 of 620 nM, Dmax, 10 µM of 80%, in MIA PaCa-2 cells.
JWJ-01-306 induces otent ZBTB11 degradation and off-target degradation of three related C2H2 ZF transcription factors: ZFP91, ZBTB21 and WIZ, in MIA PaCa-2 cells, but not GSPT1.
JWJ-01-306 promotes formation of the CRBN:molecular glue:ZBTB11 ternary complex.
JWJ-01-306 induces OXPHOS downregulation and reprogramming of mitochondrial metabolism in PDAC cells.
JWJ-01-306 resensitizes KRAS inhibitor-resistant PDAC cells to sotorasib, does not show significantly impaired proliferation alone, counters KRAS inhibitor resistance in multiple types of mutant KRAS-driven PDAC.
JWJ-01-306 reprograms the pancreatic cancer cell transcriptome and proteome to counter the high-OXPHOS drug-resistant state.
Physicochemical Properties
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M.Wt
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574.99
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Formula
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C28H26ClF3N4O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(3-((3-(1-((4-chloro-3-(trifluoromethyl)phenethyl)amino)cyclobutyl)phenyl)amino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)piperidine-2,6-dione
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References
1. Tran NL, et al. Nat Chem Biol. 2025 Aug 11. doi: 10.1038/s41589-025-01978-1.
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