JWJ-01-368

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Chemical Structure : JWJ-01-368

Catalog No.: PC-25326Not For Human Use, Lab Use Only.

JWJ-01-368 is a negative control compound of JWJ-01-306, which lacks the aromatic CF3 substituent crucial for achieving potent ZBTB11 degradation, efficiently binds CRBN but failed to promote both ZBTB11 ternary complex formation and ZBTB11 degradation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	506.99
Formula	C27H27ClN4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-((3-(1-((3-chlorophenethyl)amino)cyclobutyl)phenyl)amino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)piperidine-2,6-dione

References

1. Tran NL, et al. Nat Chem Biol. 2025 Aug 11. doi: 10.1038/s41589-025-01978-1.

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JWJ-01-368

Biological Activity

Physicochemical Properties

References

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