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Chemical Structure : JWZ-1-80
Catalog No.: PC-21276Not For Human Use, Lab Use Only.
JWZ-1-80 is a potent and selective PROTAC degrader of PI5P4Kγ with Kd of 510 nM, 1 uM induces 75% reduction of PI5P4Kγ in Molt4 cells.
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JWZ-1-80 is a potent and selective PROTAC degrader of PI5P4Kγ with Kd of 510 nM, 1 uM induces 75% reduction of PI5P4Kγ in Molt4 cells.
JWZ-1-80 exhibits VHL-dependent mechanism for compound-induced degradation of PI5P4Kγ.
JWZ-1-80 does not induce degradation of PI5P4Kα or PI5P4Kβ, shows high specificity across the entire proteome.
| M.Wt | 1019.24 | |
| Formula | C56H62N10O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wenzhi Ji, et al. Eur J Med Chem, 2023 Feb 5:247:115027.
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