JYQ-173 | DJ-1/PARK7 inhibitor | Probechem Biochemicals

Chemical Structure : JYQ-173

JYQ-173 (JYQ173)

Catalog No.: PC-22304Not For Human Use, Lab Use Only.

JYQ-173 (JYQ173) is a potent, highly selective Parkinson disease protein 7 (PARK7/DJ-1) inhibitor with IC50 of 19 nM, binds covalently and selectively to PARK7 Cys106.

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Biological Activity

JYQ-173 (JYQ173) is a potent, highly selective Parkinson disease protein 7 (PARK7/DJ-1) inhibitor with IC50 of 19 nM, binds covalently and selectively to PARK7 Cys106.

Physicochemical Properties

M.Wt	466.50
Formula	C21H19FN8O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-Cyano-N-(5-(2-fluoro-5-(1H-1,2,3-triazol-1-yl)benzoyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)pyrrolidine-3-carboxamide

References

1. Jia Y, et al. J Med Chem. 2024 May 7. doi: 10.1021/acs.jmedchem.3c02410.

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JYQ-173 (JYQ173)

Biological Activity

Physicochemical Properties

References

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