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Chemical Structure : JZL184
CAS No.: 1101854-58-3
Catalog No.: PC-20486Not For Human Use, Lab Use Only.
JZL184 (JZL 184) is a potent, selective and irreversible MAGL inhibitor, blocks 2-Arachidonoylglycerol (2-AG) hydrolysis in brain membranes with IC50 of 8 nM, >300-fold selectivity for MAGL over FAAH.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $198 | In stock | |
| 100 mg | $298 | In stock | |
| 200 mg | $428 | In stock | |
| 1 g | Get quote |
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JZL184 (JZL 184) is a potent, selective and irreversible MAGL inhibitor, blocks 2-Arachidonoylglycerol (2-AG) hydrolysis in brain membranes with IC50 of 8 nM, >300-fold selectivity for MAGL over FAAH.
JZL184 increases 2-AG but not AEA concentrations in mouse brain.
JZL184-treated mice exhibited a broad array of CB1-dependent behavioral effects, including analgesia, hypothermia and hypomotility.
JZL184 attenuated mechanical and cold allodynia via a CB(1), but not a CB(2), receptor mechanism of action.
JZL184 prolongs depolarization-induced suppression of excitation (DSE) in Purkinje neurons in cerebellar slices and DSI in CA1 pyramidal neurons in hippocampal slices.
| M.Wt | 520.49 | |
| Formula | C27H24N2O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
O=C(N1CCC(C(C2=CC=C(OCO3)C3=C2)(C4=CC=C(OCO5)C5=C4)O)CC1)OC6=CC=C([N+]([O-])=O)C=C6 |
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1. Long JZ, et al. Nat Chem Biol. 2009 Jan;5(1):37-44.
2. Kinsey SG, et al. J Pharmacol Exp Ther. 2009 Sep;330(3):902-10.
3. Pan B, et al. J Pharmacol Exp Ther. 2009 Nov;331(2):591-7.
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