Chemical Structure : Jaktinib hydrochloride
CAS No.:
2056097-82-4
Jaktinib hydrochloride
(Gecacitinib, Momelotinib-3,3,5,5-d4)
Catalog No.: PC-27965Not For Human Use, Lab Use Only.
Jaktinib hydrochloride (Gecacitinib, Momelotinib-3,3,5,5-d4) is a deuterated form of momelotinib and selective JAK1/2 inhibitor with IC50 of 0.1 μM on cells transformed by selected oncogenic mutants of tyrosine kinases, inhibits activity of JAK1, JAK2, JAK3, and TYK2, blocks the JAK-STAT signaling pathway.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Jaktinib hydrochloride (Gecacitinib, Momelotinib-3,3,5,5-d4) is a deuterated form of momelotinib and selective JAK1/2 inhibitor with IC50 of 0.1 μM on cells transformed by selected oncogenic mutants of tyrosine kinases, inhibits activity of JAK1, JAK2, JAK3, and TYK2, blocks the JAK-STAT signaling pathway.
Physicochemical Properties
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M.Wt
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454.95
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Formula
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C23H19D4ClN6O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(Cyanomethyl)-4-(2-((4-(morpholino-3,3,5,5-d4)phenyl)amino)pyrimidin-4-yl)benzamide hydrochloride
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References
1. Jingrui Liu, et al. Front Pharmacol. 2020 Dec 14:11:604314.
2. Zhang Y, et al. Blood Cancer J. 2024 Dec 18;14(1):216.
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