Catalog No.: PC-27579Not For Human Use, Lab Use Only.
K303MP20 (MP20) is a small molecule inhibitor of orphan GPCR GPRC5B and GPRC5C dimerization, inhibits GPRC5B/C-mediated modulation of EP2, IP, and AT1 signaling in vitro and in vivo.
K303MP20 (MP20) is a small molecule inhibitor of orphan GPCR GPRC5B and GPRC5C dimerization, inhibits GPRC5B/C-mediated modulation of EP2, IP, and AT1 signaling in vitro and in vivo.
MP20 inhibits GPRC5B/GPRC5C-mediated facilitation of EP2 signaling not only in HEK cells, but also in primary mouse and human macrophages.
MP20 reduces butaprost-induced cAMP production and facilitated migration in resident peritoneal macrophages (RPMs).
MP20 inhibits butaprost-induced cAMP production in human blood monocyte.
MP20 improves host defense both in bacterial peritonitis and influenza A virus infection.
MP20 reduces smooth muscle cells (SMCs) contractility and protects from arterial hypertension.
