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Chemical Structure : KAN0438757
CAS No.: 1451255-59-6
Catalog No.: PC-35684Not For Human Use, Lab Use Only.
KAN0438757 (KAN-0438757) is a potent, selective PFKFB3 inhibitor, the ester prodrug of KAN0438241 with enhanced cell permeability.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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KAN0438757 (KAN-0438757) is a potent, selective PFKFB3 inhibitor, the ester prodrug of KAN0438241 with enhanced cell permeability.
KAN0438757 impairs recruitment of ribonucleotide reductase M2 and deoxynucleotide incorporation upon DNA repair, and reduces dNTP levels.
KAN0438757 selectively inhibits proliferation of transformed cells while sparing nontransformed cells.
KAN0438757 demonstrates significant suppression of intracellular F-2,6-P2 levels with sub µM IC50 values in cell lines representing pancreatic, gastric, and colon cancer (IC50=0.24 uM in Mia Paca-2 cells).
| M.Wt | 447.433 | |
| Formula | C21H18FNO7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-hydroxyethyl 4-((5'-fluoro-2'-hydroxy-[1,1'-biphenyl])-3-sulfonamido)-2-hydroxybenzoate |
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1. Gustafsson NMS, et al. Nat Commun. 2018 Sep 24;9(1):3872.
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