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Chemical Structure : KD025
CAS No.: 911417-87-3
Catalog No.: PC-73191Not For Human Use, Lab Use Only.
KD025 (Belumosudil, SLx-2119) is a potent, selective ROCK2 inhibitor with IC50 of 105 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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KD025 (Belumosudil, SLx-2119) is a potent, selective ROCK2 inhibitor with IC50 of 105 nM.
KD025 displays >200-fold selectivity over ROCK1 (IC50>20 uM).
KD025 dose-dependently reduced infarct volume after transient middle cerebral artery occlusion, cortical perfusion in a distal middle cerebral artery occlusion model.
KD025 significantly diminished STAT3 phosphorylation and binding to IL-17 and IL-21 promoters and reduced IRF4 and nuclear hormone RAR-γt protein levels in T cells derived from healthy subjects or rheumatoid arthritis patients.
KD025 in vivo down-regulates the progression of collagen-induced arthritis in mice via targeting of the Th17-mediated pathway.
KD025 inhibits the secretion of IL-21, IL-17, and INF-γ along with decreasing p-STAT3 and reduced protein expression of IRF4 and BCL6 in human PBMCs purified from active cGVHD patients.
| M.Wt | 452.518 | |
| Formula | C26H24N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(3-(4-((1H-Indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide |
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1. Flynn R, et al. Blood. 2016 Apr 28;127(17):2144-54.
2. Zanin-Zhorov A, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16814-9.
3. Lee JH, et al. Ann Clin Transl Neurol. 2014 Jan 1;1(1):2-14.
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